Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Hoang Le Tuan Anh, Do Thi Thao, Duong Thi Dung, Phan Van Kiem, Tran Hong Quang, Pham Thi Hai Yen, Do Thanh Tuan, Pham Viet Cuong, Le Canh Viet Cuong, Tran Manh HungAbstractA comprehensive phytochemical investigation of the dichloromethane-soluble fraction of Physalis angulata led to the isolation of eight compounds (1–8) including two new withanolides named physagulin P and Q (compounds 5 and 8). Their chemical structures were established using two-dimensional nuclear magnetic resonance (spectroscopy. The cytotoxic activity of these metabolites was investigated against A549, HeLa, and PANC-1 cancer cell lines. Among them, compound 1 showed significant cytotoxic activity against A549 cells with a half-maximal inhibitory concentration (IC50) value of 8.27 μM, while compound 7 showed the most potent activity against PANC-1 cells with an IC50 value of 3.18 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research