Four new megastigmane glycosides from the leaves of Eucommia ulmoides Oliver

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jian-Kun Yan, Xu-Liu Shi, Paul Owusu Donkor, Li-Qin Ding, Feng QiuAbstractFour new megastigmane glycosides, eucomegastigsides E1 (1), eucomegastigsides E2 (2), eucomegastigsides F1 (3), and eucomegastigsides F2 (4) were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis and their absolute configurations were determined by comparison of experimental optical rotation (OR) to DFT calculations. In addition, compounds 1-4 were evaluated for their ACE (Angiotensin Converting Enzyme) inhibitory activities using HPLC. All compounds showed moderate inhibitory effects on ACE.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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