Autoimmune reactions and paraneoplastic syndromes.

[Autoimmune reactions and paraneoplastic syndromes]. Radiologe. 2018 Sep 20;: Authors: Lieb JM, Naumann N, Ahlhelm FJ Abstract CLINICAL ISSUE: Autoimmune disorders of the central nervous system (CNS) are common but are also a heterogeneous group of diseases. The most common form is multiple sclerosis (MS), others are clinically isolated syndrome (CIS), acute demyelinating encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD). Paraneoplastic syndromes are rare and tumor-associated, they are not induced by direct invasion of tumor tissue but by tumor-associated autoantibodies mostly against specific CNS proteins, e. g. limbic encephalitis and paraneoplastic cerebellar ataxia or degeneration. DIAGNOSTICS, STANDARD RADIOLOGICAL METHODS, PERFORMANCE AND ACHIEVEMENTS: The correct diagnosis of autoimmune and paraneoplastic syndromes can still be challenging. In addition to the patient history, clinical examination and blood as well as cerebrospinal fluid (CSF) tests, magnetic resonance imaging (MRI) is gaining importance in the diagnostics. It is important not only in primary diagnostics but also in follow-up and therapy monitoring, especially in MS with specific therapies to detect therapy complications, such as progressive multifocal leukoencephalopathy as early as possible. In paraneoplastic syndromes MRI can also be an important component in the diagnostics but can also initially be negative and typical signal changes become vi...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research

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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research
Authors: Suo F, Zhong B, Lu F, Dong Z Abstract Glioma is the most aggressive brain tumor and is associated with a high mortality rate. The aim of the present study was to explore the association between matrix metalloproteinase 2 (MMP-2) and ephrin type-A receptor 2 (EphA2) expression in glioma cells, and to investigate the contribution of magnetic resonance imaging (MRI) in glioma classification. A total of 43 patients with pathologically confirmed glioma were divided into two groups as follows: Low-grade (grades I and II; n=21) and high-grade (grades IV and IV; n=22). Subsequently, immunohistochemistry staining w...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, a novel yet reliable method for the measurement of intracellular 18F-FDG via GS has been developed, and our results indicate that 18F-FDG uptake is associated with radiation and cetuximab response in HNSCC. PMID: 31620196 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
We present unusual treatment outcome in a 59-year-old male diagnosed with metastatic lung adenocarcinoma with a very good response to ruxolitinib as monotherapy. In June 2017, this patient was diagnosed with myeloproliferative neoplasm – Janus-associated kinases 2 positive – and in December 2017 ruxolitinib therapy was started. At the same time, patient was diagnosed with lung adenocarcinoma in the left lower lobe with positive anaplastic lymphoma kinase mutation and with right lower lobe metastasis. Because of partial regression of tumor size noted on the computed tomography (CT) scans during tumor investigati...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
We describe a case involving a 67-year-old ovarian cancer patient who underwent multiple lines of chemotherapy and presented with recurrent disease and a CA-125 of 4112 U/mL. Thenceforth, she was treated with GL-ONC1 oncolytic viral therapy that was administered laparoscopically in accordance with a clinical trial. The patient subsequently received chemotherapy and during the fourth cycle, her CA-125 decreased to 99 U/mL; moreover, a computed tomography scan of the pelvis exhibited significant disease reduction. Viral therapy hypothetically confers significant promise in the treatment of recurrent ovarian cancer, especiall...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
Authors: Macomb CV, Evans MO, Dockstater JE, Montgomery JR, Beakes DE Abstract Shoulder injury related to vaccine administration (SIRVA) is defined as "shoulder pain with limited range of motion within 48 hours after vaccine receipt in individuals with no prior history of pain, inflammation, or dysfunction of the affected shoulder before vaccine administration." Corticosteroid injections (CSIs) have been proposed as a reasonable treatment modality for SIRVA, although evidence regarding efficacy is scanty. In this case series, we present two patients diagnosed with SIRVA who received CSI within 5 days of s...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Publication date: Available online 16 October 2019Source: Food ChemistryAuthor(s): Peng Wang, Yang Li, Cen Zhang, Fengqin Feng, Hui ZhangAbstractIn this work, sequential electrospinning was utilized to fabricate a multilayer film with ethylcellulose nanofibers as the outer layer and curcumin-loaded gelatin nanofibers as the inner layer. Field-emission scanning electronic microscopy observations showed that the outer and inner layers had a smooth surface and clear boundary. The hydrophobic outer layers decreased the water vapor permeability and improved the water contact resistance of the hydrophilic inner layer, and the in...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 15 October 2019Source: Food ChemistryAuthor(s): Yingying Zhang, Wanjun Gao, Chuanjian Cui, Zhengzhu Zhang, Lili He, Jinkai Zheng, Ruyan HouAbstractThe tenderness of the fresh tea leaves can affect the quality of tea products. It is important to develop a mechanized, accurate way to evaluate the quality of fresh leaves that avoids the uncertainty of a subjective evaluation. Herein, an in-situ, ultra-rapid Raman microscopy strategy to quantify carotenoids in tea leaves was established. The Raman microscopy of carotenoids distribution in leaves from new branches of 22 representative tea vari...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: January 2020Source: Radiation Physics and Chemistry, Volume 166Author(s): Muhammad Zubair, Rafik Hazem, Ishaq Ahmad, M. Imtiaz Khan, Ting-kai Zhao, Hazrat Ali, Tariq Ali, Muhammad Arshad, Fida Rehman, Pervaiz Ahmad, Mahmoud IzerroukenAbstract5 MeV carbon ion irradiation effects on micro-fine grain graphite samples are investigated. The X-ray diffraction (XRD), Raman spectroscopy, field emission scanning electron microscope (FESEM), and high-resolution transmission electron microscope (HRTEM) are used to study changes due to irradiation. At a dose of 0.5 dpa, the isolated defects (monovacancies) were gen...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): S. Madhankumar, P. Muthuraja, M. DhandapaniAbstractA new organic non-linear optical crystal, 2-amino-4-methylpyridinium benzilate (2-A4MPB) was synthesized and single crystals were grown by slow evaporation-solution growth method at 30 °C using methanol as solvent. The FT-IR spectroscopic analysis confirmed the presence of characteristic functional groups in the title compound. The 1H and 13C NMR spectra were recorded to establish the molecular structure. The thermogravimetric and differential thermal analyses were carried ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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