Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs.
CONCLUSION: Ganaxolone improved neurobehavioural outcomes in males suggesting that neonatal treatment may be an option for reducing preterm-associated neurodevelopmental impairment. However, dosing studies are required to reduce the burden of unwanted side effects.
PMID: 30237570 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Shaw JC, Dyson RM, Palliser HK, Gray C, Berry MJ, Hirst JJ Tags: Pediatr Res Source Type: research
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