Spontaneous eyeblinks are sensitive to sequential learning

Publication date: Available online 21 September 2018Source: NeuropsychologiaAuthor(s): Estibaliz San Anton, Axel Cleeremans, Arnaud Destrebecqz, Philippe Peigneux, Rémy SchmitzAbstractAlthough sequential learning and spontaneous eyeblink rate (EBR) have both been shown to be tightly related to cerebral dopaminergic activity, they have never been investigated at the same time. In the present study, EBR, taken as an indirect marker of dopaminergic activity, was investigated in two resting state conditions, both before and after visuomotor sequence learning in a serial reaction time task (SRT) and during task practice. Participants’ abilities to produce and manipulate their knowledge about the sequential material were probed in a generation task. We hypothesized that the time course of spontaneous EBR might follow the progressive decrease of RTs during the SRT session. Additionally, we manipulated the structure of the transfer blocks as well as their respective order, assuming that (1) fully random trials might generate a larger psychophysiological response than an unlearned but structured material, and (2) a second (final) block of transfer might give rise to larger effects given that the sequential material was better consolidated after further practice. Finally, we tentatively hypothesized that, in addition to their online version, spontaneous EBR recorded during the pre- and post-learning resting sessions might be predictive of (1) the SRT learning curve, (2) the magnitud...
Source: Neuropsychologia - Category: Neurology Source Type: research