Can haploidentical transplantation meet all patients’ needs?

Publication date: Available online 21 September 2018Source: Best Practice & Research Clinical HaematologyAuthor(s): Daniel WeisdorfAllotransplantation in the absence of an HLA-matched sibling donor can offer numerous donor options including unrelated donor and umbilical cord blood grafting. Recently, haploidentical transplantation has exploded in popularity and worldwide use following the application of post-transplant cyclophosphamide (PTCy) for GVHD prophylaxis. Various approaches, disease states, conditioning intensities and supportive care advances have improved all these choices without demonstrable superiority of one approach versus the others. However, PTCy limits risks of GVHD; bone marrow over peripheral blood stem cells limits risks of chronic GVHD, which suggests that both these promising techniques can inform these donor and graft choices. Formal and prospective data will answer whether situationally adapted best options—tailored to each patient’s disease risk and comorbidity status—will help guide future decision-making to improve patient outcomes with the least cumulative morbidity.
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research