Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia
We report the successful treatment of an adolescent male with B-cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement. The strategies described could be applied to other MDR fungal infections.
Publication date: Available online 15 May 2020Source: Journal of Ginseng ResearchAuthor(s): Sirui Zhu, Xiaoli Liu, Mei Xue, Yu Li, Danhong Cai, Shijun Wang, Liang Zhang
Publication date: Available online 30 May 2020Source: Seminars in Cancer BiologyAuthor(s): Xiaohua Lu, Thomas Efferth
Publication date: Available online 30 April 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Alessandra Malato, Elena Rossi, Mario Tiribelli, Francesco Mendicino, Novella Pugliese
Authors: Dong A, Yang W, Huang H, Zhou X, He Z, Yao R, Guo W Abstract Changes in histone H3 lysine 9 trimethylation (H3K9me3) may be related to the development of drug‑resistant acute myeloid leukaemia (AML); insights into the network of H3K9me3 may improve patient prognosis. Patient data were derived from the Gene Expression Omnibus (GEO) database and data from AML cells treated with chidamide, a novel benzamide chemical class of histone deacetylase inhibitor (HDACi), in vitro were derived from ChIP‑seq. Patients and AML cell data were analysed using GEO2R, GOseq, KOBAS, the STRING database and Cytoscape ...
In this study, we analyzed the distribution of Mycobacterium species, compare the diagnostic methods, and susceptibilities to anti-tuberculosis drugs of TB isolates. The aim was to document the current status and to provide a frame of reference for future studies. In this study, 278 Mycobacterium species isolated from 7,480 patients between September 2015 and June 2019 were included. Löwenstein-Jensen medium (LJ) and MGIT 960 were used for the isolation of strains. Susceptibility to 1st-line anti-tuberculosis drugs was determined. Positivity rates in clinical samples were as follows: 1.4% for direct microscopic acid-f...
The MD Anderson Cancer Center expert discussed why there is an unmet need for more treatments in patients with IDH1-mutated acute myeloid leukemia.
In conclusion, we highlight a novel and clinically exploitable pathway in high-risk EZH2 mutated T-ALL.
In conclusion, we described a myeloid NKL-code and several deregulated NKL homeobox genes in AML. We identified for NKL homeobox gene NANOG deregulating factors and downstream activities in AML. These data indicate a common oncogenic role of NKL homeobox genes in myeloid malignancies.
CONCLUSION: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation. PMID: 32469169 [PubMed - in process]
CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. PMID: 32469177 [PubMed - in process]