Cognition-related white matter integrity dysfunction in Alzheimer's disease with diffusion tensor image.

Cognition-related white matter integrity dysfunction in Alzheimer's disease with diffusion tensor image. Brain Res Bull. 2018 Sep 18;: Authors: Li Y, Feng F, Lin P, Huang Z, Liu T, Zhou B, Yao H, Zheng L, Li C, Wang P, Zhang Z, Guo Y, Wang L, An N, Zhu X, Zhang X, Wang J Abstract Alzheimer's disease (AD) is a worldwide progressive neurodegenerative disorder in the elderly. Previous research has indicated that Alzheimer's disease impairs white matter (WM) tracts. Anatomical and neuroimaging studies have indicated that WM tracts are associated with cognitive function. Whether the abnormal WM integrity in AD is associated with cognitive impairments and the clinical symptoms is still not clear. To this end, we investigated the relationship between the impairments in WM tracts and the decline of cognitive ability in AD. Diffusion tensor imaging (DTI) data were collected from 38 AD patients and 30 normal, cognitively healthy volunteers. The tract-based spatial statistics (TBSS) approach was used to compare the fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups. WM tracts (cingulum, superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), and inferior longitudinal fasciculus (ILF)) associated with cognition function were extracted for region of interest (ROI)-based analysis. Significantly decreased FA values and increased MD values of the cognition-related WM tracts were observed in the AD group comp...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research