Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies

ConclusionBeing HSP27 involved in several pathological conditions, including protein conformational diseases (i.e Cystic Fibrosis) and cancer, the need of drugs to modulate its activity is growing and CK2-targeting could represent a new strategy to reduce cellular HSP27 level.General significanceThis study identifies CK2 as a molecular target to control HSP27 cellular expression.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research