The impact of age at the time of radiotherapy for localized prostate cancer on the development of second primary malignancies

Radical prostatectomy (RP) and radiotherapy (RT) represent the main treatment modalities for localized prostate cancer (CaP) [1]. RT is also used in the adjuvant setting for patients with pT3 CaP or positive surgical margins, and as salvage treatment for biochemical failure after RP. As treatments become more effective, the increase in survivorship has led to the observation of second primary malignancies (SPMs) in cancer survivors. Radiation is believed to contribute to development of SPMs, and studies have shown relationships between radiation, urothelial dysplasia, and DNA damage [2,3].

Source: Urologic Oncology: Seminars and Original Investigations - September 21, 2018 Category: Urology & Nephrology Authors: Ross E. Krasnow, Dayron Rodr íguez, Ramzy T. Nagle, Matthew Mossanen, Adam S. Kibel, Steven L. Chang Source Type: research