The LURN research network neuroimaging and sensory testing (NIST) study: Design, protocols, and operations

The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls.

Source: Contemporary Clinical Trials - September 21, 2018 Category: Radiology Authors: H. Henry Lai, Bruce Naliboff, Alice B. Liu, Cindy L. Amundsen, Joshua S. Shimony, Vincent A. Magnotta, Joseph J. Shaffer, Robin L. Gilliam, Jonathan B. Wiseman, Margaret E. Helmuth, Victor P. Andreev, Ziya Kirkali, Steven E. Harte, The LURN Study Group Source Type: research