Contact Lenses May Harbor Serious, Blinding Infection
FRIDAY, Sept. 21, 2018 -- Contact lens wearers everywhere need to be on the lookout for a rare, but potentially blinding, eye infection, British researchers warn. In southeast England, cases of the infection, called Acanthamoeba keratitis, have...
Conclusions: This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient. Further clinical evidence would be needed to possibly incorporate this medication in the antiamoebic armamentarium.
Species of Acanthamoeba are facultative pathogens which can cause sight threatening Acanthamoeba keratitis and a rare but deadly brain infection, granulomatous amoebic encephalitis. Due to conversion of Acanthamo...
PMID: 31095535 [PubMed - in process]
Conclusions: Consensus among stakeholders about water and CL care is needed. Guidelines should unequivocally advocate for the avoidance of any water exposure including handling CLs with wet hands, rinsing CLs or storage cases in tap water, showering while wearing CLs and swimming with CLs without wearing goggles.
ConclusionEven in advanced cases with ring infiltrate, eradication of infection with anti-amoebic drugs is possible. In those requiring keratoplasty, the surgical timing should be made meticulously considering graft size and signs of dilated pupil/iris atrophy in terms of post-operative glaucoma.
CONCLUSION: Even in advanced cases with ring infiltrate, eradication of infection with anti-amoebic drugs is possible. In those requiring keratoplasty, the surgical timing should be made meticulously considering graft size and signs of dilated pupil/iris atrophy in terms of post-operative glaucoma. PMID: 31076316 [PubMed - as supplied by publisher]
Acanthamoeba Keratitis (AK) is a relatively uncommon but sight-threatening infection of the cornea . Historically, the strongest risk factor for AK has been contact lens (CL) wear though AK can still occur in non-CL wearers.
Abstract Acanthamoeba castellanii belonging to the T4 genotype may cause fatal brain infection known as granulomatous amoebic encephalitis, and vision-threatening eye infection Acanthamoeba keratitis. The aim of this study was to evaluate the antiamoebic effects of three clinically available antidiabetic drugs Glimepiride, Vildagliptin and Repaglinide against A. castellanii belonging to the T4 genotype. Furthermore, these drugs were attempted to conjugate with silver nanoparticles (AgNPs) to enhance antiamoebic effects. Amoebicidal, encystation, excystation, and host cells cytotoxicity assays were performed to unr...
WARNING: GRAPHIC CONTENT Traci Lawson, 50, from Lansing, Michigan, was diagnosed with Acanthamoeba keratitis, a parasitic infection from poor contact lens hygeine.
Conclusions: Reduction in Acanthamoeba cyst density with treatment can be monitored by IVCM, which in turn can be used clinically in prognostication and disease monitoring of AK.