Chromatin Domains Go on Repeat in Disease

Publication date: 20 September 2018Source: Cell, Volume 175, Issue 1Author(s): Benoit G. Bruneau, Elphège P. NoraTAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington’s disease.
Source: Cell - Category: Cytology Source Type: research