Lyme disease: A study on the speed of transmission by infected ticks

(Institut Pasteur) Lyme borreliosis is a disease caused by bacteria of the genus Borrelia that are transmitted by a bite from a tick of the genus Ixodes. Scientists from the Institut Pasteur found evidence of rapid bacterial transmission following a bite, with infection occurring within 24 hours of an adult tick bite. This is a timely reminder of the importance of removing ticks as soon as possible after being bitten to prevent infection.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Publication date: Available online 18 April 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Eliza A.H. Little, John F. Anderson, Kirby C. Stafford, Lars Eisen, Rebecca J. Eisen, Goudarz MolaeiAbstractLyme disease is the most prevalent vector-borne disease in the United States. Ixodes scapularis, commonly referred to as the blacklegged tick, is the primary vector of Lyme disease spirochetes, Borrelia burgdorferi sensu lato (s.l.), in the eastern United States. Connecticut has pervasive populations of I. scapularis and remains a hotspot for Lyme disease. A primary aim of this study was to determine if passively collected...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
John R. Caskey1,2†, Nicole R. Hasenkampf1, Dale S. Martin1, Vladimir N. Chouljenko2, Ramesh Subramanian2, Mercedes A. Cheslock1 and Monica E. Embers1* 1Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, LA, United States 2Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, United States Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in the presence of microbiostatic drugs such as doxycycline. Precisely how this...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: July 2019Source: Biomedicine &Pharmacotherapy, Volume 115Author(s): Hua Zhao, Xiting Dai, Xinlin Han, Aihua Liu, Fukai Bao, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Manzama-Esso Abi, Taigui Chen, Lisha Luo, Mingbiao Ma, Lvyan TaoAbstractLyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an importa...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study provides insight into the microbial diversity of I. scapularis in New York State and Connecticut.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Abstract Lyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an important role in Lyme arthritis. Toll-like receptors (TLRs) recognize and bind to pathogen-associated molecules which are structurally conserved among microbes, to activate transcriptional events, including cytokine production, inflammation, and tissue da...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Charlotte Mason1, Xiaoyan Liu2, Spoorthy Prabhudeva1 and Zhiming Ouyang1* 1Department of Molecular Medicine, University of South Florida, Tampa, FL, United States 2Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States BosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. Unlike typical Fur proteins in which DNA binding represses gene expression, binding of BosR to the rpoS promoter directly activates rpoS transcription in B. burgdorferi. However, virtually nothing is known concerning potential structural fea...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 14 April 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Elisa Martello, Alessandro Mannelli, Elena Grego, Leonardo Adrian Ceballos, Charlotte Ragagli, Maria Cristina Stella, Laura TomassoneAbstractTicks and ear biopsies were collected from wild small rodents in 2011 and 2012 in the northern Apennines (Italy), up to 1650 m above sea level. Apodemus spp. (n = 83) and Myodes glareolus (n = 22) were infested by Ixodes ricinus (192 larvae and two nymphs), Dermacentor marginatus (179 larvae and 29 nymphs), and Ixodes trianguliceps (three larvae and two ny...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 14 April 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Xiuqin Zhong, Mehrnaz Nouri, Lars RåbergAbstractStudies of Borrelia burgdorferi sensu lato in laboratory mice and humans have shown that spirochaetes disseminate from the site of infection (skin) to internal tissues, and cause various pathological effects. However, less is known about colonization and pathology of Lyme borreliosis spirochaetes in their natural hosts. In the present study, we assessed the colonization and manifestations during B. afzelii infection in reservoir hosts (yellow-necked mouse, Apodemus flavicolli...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Tania Rahman1,2†‡, Andrew S. Brown2‡, Elizabeth L. Hartland1‡, Ian R. van Driel2* and Ka Yee Fung1†‡ 1Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia 2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen Citrobacter rodentium, an organism tha...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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