Hierarchical control of interleukin 13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11 [Signal Transduction]

In this study, we identified IL-13–induced transcriptional factors in lung fibroblasts using DNA microarrays in which SOX11 was included. Knockdown of SOX11 down-regulated expression of periostin and CCL26, both of which are known to be downstream molecules of IL-13, whereas enforced expression of SOX11 together with IL-13 stimulation enhanced expression of periostin. Moreover, we found that in DNA microarrays combining IL-13 induction and SOX11 knockdown there exist both SOX11-dependent and -independent molecules in IL-13–inducible molecules. In the former, many inflammation-related and fibrosis-related molecules, including periostin and CCL26, are involved. These results suggest that SOX11 acts as a trans-acting transcriptional factor downstream of STAT6 and that in lung fibroblasts the IL-13 signals are hierarchically controlled by STAT6 and SOX11.

Source: Journal of Biological Chemistry - September 21, 2018 Category: Chemistry Authors: Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Kazuhiko Arima, Tomohito Yoshihara, Kosaku Komiya, Shogo Fukuda, Hiroaki Takatori, Hiroshi Nakajima, Masutaka Furue, Kenji Izuhara Tags: Immunology Source Type: research