Nephrotoxicity and highly active antiretroviral therapy: Mitigating action of Momordica charantia

Publication date: Available online 20 September 2018Source: Toxicology ReportsAuthor(s): Ugochukwu Offor, Edwin Coleridge Naidu, Oluwatosin Olalekan Ogedengbe, Ayoola Isaac Jegede, Aniekan Imo Peter, Onyemaechi Okpara AzuAbstractMomordica charantia (M. charantia) is known for its antioxidant and antidiabetic properties. The aim of this study is to investigate the renoprotective effects of M. charantia in rats following treatment with highly active antiretroviral therapy (HAART) regimen triplavar. Adult male Sprague-Dawley rats weighing 178.1–220.5 g (n = 36) were divided into six groups (A–F) with each group comprising of six (n = 6) rats. The drugs and extract were administered via oral gavage. The therapeutic dose of triplavar was adjusted using the human therapeutic dose equivalent for the rat model. Animals were euthanized on the tenth week with kidneys removed for examination and blood obtained via cardiac puncture. Levels of oxidative stress enzymes (superoxide dismutase-SOD, catalase-CAT, and reduced glutathione-GSH) were significantly lowered in all groups not receiving M. charantia. The levels of thiobarbituric acid reactive substances (TBARS) were increased resulting in free radical formation via auto-oxidation. Renal parameters showed no albuminuria, normal blood urea nitrogen (BUN), serum creatinine (SCr) and electrolytes in groups treated with M. charantia. HAART treated (Group B) showed severe albuminuria, a signifi...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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Source: BMC Immunology - Category: Allergy & Immunology Authors: Tags: Research article Source Type: research
No abstract available
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Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: OCULAR MANIFESTATIONS OF SYSTEMIC DISEASE: Edited by John A. Gonzales Source Type: research
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