Precision of the reportable value—Statistical optimization of the number of replicates

Publication date: 5 January 2019Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 162Author(s): Richard K. Burdick, Joachim ErmerAbstractIn pharmaceutical analysis, the precision of the reportable value, i.e. the result which is to be compared to the specification limit(s), is relevant for the suitability of the analytical procedure. Using the variance contributions determined in precision studies addressing the levels injection/system precision, repeatability, and intermediate precision, the number of the corresponding replications for analysis/injection, sample preparation, and series/runs can be varied to improve the precision of the mean (reportable) value (Ermer, Agut, J.Chromatogr. A, 1353 (2014) 71–77). However, this calculation will provide only information on the gain for the precision of the calculated reportable value itself. These so-called point estimators have uncertainty associated with them which can be quantified using statistical confidence intervals. Commonly used statistical equations only allow one to calculate confidence intervals for the intermediate precision of the reportable value, which requires that the routine replication strategy must be defined before starting the precision study.In this paper, statistical models are presented that allow optimizing efficiently the replication strategy with respect to the confidence interval of the precision based on the Satterthwaite approximation posterior, i.e. using the results from the ...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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ConclusionsThe use of adhesive can improve masticatory performance of new complete dentures users with normal mandibular ridges in the initial adaptation period up to 60 days after insertion. For resorbed ridges subjects, the use of adhesive had a negative impact on masticatory discomfort/disability OHRQoL at 30 days after insertion.
Source: Journal of Prosthodontic Research - Category: Dentistry Source Type: research
ConclusionEATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout. Hence the EATP was found to be helpful in the treatment of gout.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 August 2019Source: Journal of Ginseng ResearchAuthor(s): Moon Young Park, Se Jik Han, Donggerami Moon, Sangwoo Kwon, Jin-Woo Lee, Kyung Sook KimAbstractBackgroundRed ginseng contains components that can be used in skincare to delay the aging process, including microelements, vitamins, essential oils, and fatty acids. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis.MethodsHuman dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using at...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ConclusionDifferentially expressed in tumors, PLA2G4A, PRKCB, PIK3R1, KDR, PLA2G1B and PTGS2 are potential therapeutic targets of Yupingfengsan in the treatment of LAD, and MAPK, VEGF and ErbB signaling pathways are involved.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Cardiology CasesAuthor(s): Shohei Kataoka, Ken Kato, Hiroyuki Tanaka, Tamotsu TejimaAbstractIt is challenging to perform ablation of ventricular tachycardia (VT) from the left ventricle (LV) in patients without catheter access to the LV. A 50-year-old man was referred to our hospital for VT. He underwent mechanical aortic and mitral valve replacement for infective endocarditis and embolic myocardial infarction in the left ventricular inferior wall during a surgery. Anti-arrhythmia drugs (AADs) such as sotalol and bisoprolol were initiated and implantable c...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Cardiology CasesAuthor(s): Takashi Ando, Hiroshi Okada, Makoto Takeda, Tomio UmemotoAbstractPeriaortitis is one of the less common manifestations of the aorta pathology. Periaortitis mostly arises from the outer layers of the abdominal aorta and iliac arteries. However, other large arteries may also be involved, but rarely the thoracic aorta. Here we present a successful conservative treatment using prednisolone therapy for periaortitis of the aortic arch which shows various clinical symptoms.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s): Julian Yeoh, Jonathan Hill
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s): David A. Power, Paul Guedeney, George D. Dangas
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s):
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
Publication date: October 2019Source: Interventional Cardiology Clinics, Volume 8, Issue 4Author(s):
Source: Interventional Cardiology Clinics - Category: Cardiology Source Type: research
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