Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

ConclusionsThis study has elucidated the genome-wide effects of several adaptogenic herbal extracts in brain cells culture. These data highlight the consistent activation of ASRSPs by adaptogens in T98G neuroglia cells. The extracts affected many genes playing key roles in modulation of adaptive homeostasis, indicating their ability to modify gene expression to prevent stress-induced and aging-related disorders. Overall, this study provides a comprehensive look at the molecular mechanisms by which adaptogens exerts stress-protective effects.Graphycal abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research