Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2 α concentrations in renal interstitial fibroblasts

Iron is an essential mineral for oxygen delivery and for a variety of enzymatic activities, but excessive iron results in oxidative cytotoxicity. Because iron is primarily used in red blood cells, defective erythropoiesis caused by loss of the erythroid growth factor erythropoietin (Epo) elevates iron storage levels in serum and tissues. Here, we investigated the effects of iron in a mouse model of Epo-deficiency anemia, in which serum iron concentration was significantly elevated. We found that intraperitoneal injection of iron-dextran caused severe iron deposition in renal interstitial fibroblasts, the site of Epo production.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research