Optimal immunosuppressor induces stable gut microbiota after liver transplantation.

CONCLUSION: Compared to the low or high dosage of FK506, an optimal dosage of FK506 induced immunosuppression, normal graft function and stable gut microbiota following LT in rats. The stable gut microbiota presented increased probiotics and decreased potential pathogenic endotoxin-producing bacteria. These findings provide a novel strategy based on gut microbiota for immunosuppressive dosage assessment for recipients following LT.
PMID: 30228781 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - September 14, 2018 Category: Gastroenterology Authors: Jiang JW, Ren ZG, Lu HF, Zhang H, Li A, Cui GY, Jia JJ, Xie HY, Chen XH, He Y, Jiang L, Li LJ Tags: World J Gastroenterol Source Type: research