High Dose Chemotherapy with Early Autologous Stem Cell Transplantation Compared to Standard Dose Chemotherapy or Delayed Transplantation in Patients with Newly Diagnosed Multiple Myeloma: A Systematic Review and Meta-analysis

High dose therapy (HDT) with autologous stem cell rescue (SCT) following induction therapy has been the standard treatment for multiple myeloma (MM) in transplant-eligible patients since the 1990s. When this approach was studied in the 1980s, HDT with SCT led to higher rates of complete response which translated into prolonged duration of remission 1,2. HDT with SCT can be in the form of a single course of HDT followed by stem cell rescue or a tandem approach where 2 planned SCTs are conducted serially.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research