The role of xenobiotic receptors on hepatic glycolipid metabolism.

The role of xenobiotic receptors on hepatic glycolipid metabolism.
Curr Drug Metab. 2018 Sep 18;:
Authors: Chen K, Zhong J, Hu L, Li R, Duc Q, Cai J, Li Y, Gao Y, Cui X, Yang X, Wu X, Yao L, Dai J, Wang Y, Jin H
Abstract
PXR (pregnane X receptor) and CAR (constitutive androstane receptor) are termed as xenobiotic receptors, which are known as core factors in the regulation of the transcription of metabolic enzymes and drug transporters. However, accumulating evidence has shown that PXR and CAR exert their effects on energy metabolism through the regulation of gluconeogenesis, lipogenesis, and β-oxidation. Therefore, PXR and CAR may become new therapeutic targets for metabolic syndrome, including obesity and diabetes. In this review, we will summarize recent advances to show how xenobiotic receptors regulate energy metabolism.
PMID: 30227815 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - September 18, 2018 Category: Drugs & Pharmacology Authors: Chen K, Zhong J, Hu L, Li R, Duc Q, Cai J, Li Y, Gao Y, Cui X, Yang X, Wu X, Yao L, Dai J, Wang Y, Jin H Tags: Curr Drug Metab Source Type: research