Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension – results from BEET-PAH an exploratory randomized, double-blind, placebo-controlled crossover study

Pulmonary arterial hypertension (PAH) is a rare, progressive, symptomatic, and ultimately fatal disease associated with a progressive elevation of the pulmonary arterial pressure and the pulmonary vascular resistance resulting in right heart failure (1). Endothelial dysfunction, a pathological feature of PAH, is attributed to the imbalance between endogenous pulmonary vasodilators and vasoconstrictors, in particular nitric oxide (NO), prostacyclin and endothelin-1 (2, 3).

Source: Journal of Cardiac Failure - September 20, 2018 Category: Cardiology Authors: Dan Henrohn, Kristoffer Bj örkstrand, Jon O. Lundberg, Sven-Olof Granstam, Tomasz Baron, Inga J. Ingimarsdóttir, Hans Hedenström, Andrei Malinovschi, Mona-Lisa Wernroth, Martin Jansson, Mikael Hedeland, Gerhard Wikström Source Type: research