Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Publication date: Available online 19 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Reza Yazdani, Hassan Abolhassani, Fatemeh Kiaee, Sima Habibi, Gholamreza Azizi, Marzieh Tavakol, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani, Tooba Momen, Mohammad Gharagozlou, Masoud Movahedi, Amir Ali Hamidieh, Nasrin Behniafard, Mohammamd Nabavi, Mohammad Hassan Bemanian, Saba Arshi, Rasol Molatefi, Roya Sherkat, Afshin Shirkani, Reza AminAbstractBackgroundPredominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses.ObjectiveWe intended to report most common monogenic PADs and to investigate how PAD patients who were primarily diagnosed as agammaglobulinemia, hyper IgM syndrome (HIgM) and common variable immunodeficiency (CVID) have different clinical and immunological findings.MethodsStepwise next generation sequencing and Sanger sequencing were performed for confirmation of the mutations in the patients clinically diagnosed as agammaglobulinemia, HIgM and CVID.ResultsAmong 550 registered patients, the predominant genetic defects associated with agammaglobulinemia (48 BTK and 6 μ heavy chain deficiencies), HIgM (21 CD40L and 7 AID deficiencies) and CVID (17 LRBA deficiency and 12 atypical ICF syndromes) were identified. Clinical disease severity was significantly higher in patients with μ heavy chain and CD40L compa...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 25 January 2020Source: International Journal of PharmaceuticsAuthor(s): Xue Zheng, Chao Sun, Rilei Yu, Xin Chu, Jiahao Xu, Chengcheng Liu, Miaoqing Zhao, Xuelian Xu, Ming Xia, Cheng WangAbstractRelapse in Allergic Rhinitis (AR) is triggered by various unclear mechanisms. Xanthium strumarium L. as a traditional folk medicine can inhibit inflammatory responses through multiple mechanisms. Xanthatin (XT) is a bioactive compound derived from Xanthium strumarium L, and we developed a polymeric micelle (PM) that is dendritic cells (DCs)-specific targeting delivery system loading XT (NGR-XT-PM) ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Federico Lavorini, Celeste Barreto, Job F.M. van Boven, Will Carroll, Joy Conway, Richard W. Costello, Birthe Hellqvist Dahl, Richard P.N. Dekhuijzen, Stephen Holmes, Mark Levy, Mathieu Molimard, Nicholas Roche, Miguel Román-Rodriguez, Nicola Scichilone, Jane Scullion, Omar S. UsmaniSpacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding ch...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 25 January 2020Source: Veterinary MicrobiologyAuthor(s): Mar Costa-Hurtado, Emili Barba-Vidal, Jaime Maldonado, Virginia AragonAbstractAntimicrobials have been commonly used to control bacterial diseases in farm animals. The efficacy of these drugs deterred the development of other control measures, such as vaccines, which are currently getting more attention due to the increased concern about antimicrobial resistance. Glässer’s disease is caused by Glaesserella (Haemophilus) parasuis and affects pork production around the world. Balance between colonization and immunity seems ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 25 January 2020Source: Preventive Veterinary MedicineAuthor(s): Andnet Yirga, Wudu T. Jemberu, Nicholas Lyons, Alemseged Gebru, Fasil Akililu, Jonathan Rushton
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Authors: Haese N, Powers J, Streblow DN Abstract Chikungunya virus (CHIKV) infection in humans is rarely fatal but is often associated with chronic joint and muscle pain. Chronic CHIKV disease is highly debilitating and is associated with viral persistence. To date, there are no approved vaccines or therapeutics to prevent or treat CHIKV infections once they are established. Current palliative treatments aim to reduce joint inflammation and pain associated with acute and chronic CHIKV disease. Development of novel therapeutics that reduces viral loads should positively impact virus inflammatory disease and improve ...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
In conclusion, although young and non-smoking volunteers considered themselves healthy by questionnaire, 20% showed signs of a heart, liver, or airway disease, and additional 24% were classified as atopics. This suggests that more detailed clinical testing may be necessary to safely exclude those who may adversely react to controlled exposure with sensory irritants. PMID: 31974924 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Publication date: 25 January 2020Source: New Scientist, Volume 245, Issue 3266Author(s): Clare WilsonCurrent baby weaning guidelines may mean we are missing a crucial window to prevent food allergies. Clare Wilson reports
Source: New Scientist - Category: Science Source Type: research
Source: Global Public Health - Category: International Medicine & Public Health Authors: Source Type: research
(CNN) — What started as a mystery virus last month in Wuhan, China, has now killed more than two dozen people and infected hundreds more around the world. In the U.S., the first cases of Wuhan coronavirus were confirmed this week — a man in his 30s who is under observation in Washington state and a Chicago woman in her 60s — stoking fears of an outbreak in this country, though health officials say the risk for Massachusetts residents getting the virus is low. So what are officials doing in the U.S., and how can you minimize your risk? What airports are doing Passengers from Wuhan to the United States &mda...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Coronavirus Source Type: news
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