3D printing and coating to fabricate a hollow bullet-shaped implant with porous surface for controlled cytoxan release

Publication date: Available online 19 September 2018Source: International Journal of PharmaceuticsAuthor(s): Ning Yang, Huanfei Chen, Huijie Han, Yuanyuan Shen, Song Gu, Yong He, Shengrong GuoAbstractIntratumoral implants have aroused great interests for local chemotherapy of cancer, however, how to efficiently control drug release from implants is still a great challenge. Herein, we designed and prepared a new hollow bullet-shaped implant with porous surface by 3D printing, loaded chemotherapeutic agent cytoxan (CTX) with tetradecyl alcohol or lecithin as matrix and coated it with poly (lactic acid) to obtain a CTX implant, which has a highly tuned drug release property with a drug release time from 4 h to more than 1 month. The drug release from the implant can be easily controlled by changing pore sizes, kinds of matrices, and coating thickness.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research