Impaired histaminergic neurotransmission in children with narcolepsy type 1.

CONCLUSIONS: Narcolepsy type 1 children had a higher CSF HA level together with a lower t-MeHA level leading to a significant decrease in the t-MeHA/HA ratios. These results suggest a decreased HA turnover and an impairment of histaminergic neurotransmission in narcoleptic children and support the use of a histaminergic therapy in the treatment against narcolepsy.
PMID: 30225986 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - September 17, 2018 Category: Neuroscience Authors: Franco P, Dauvilliers Y, Inocente CO, Guyon A, Villanueva C, Raverot V, Plancoulaine S, Lin JS Tags: CNS Neurosci Ther Source Type: research