Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6 ‐year follow‐up study

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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Authors: Albertson TE, Chenoweth JA, Pearson SJ, Murin S Abstract Introduction: Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a disease phenotype that shares T helper lymphocyte cell Th1/neutrophilic/non-Type-2 Inflammation pathways thought to be key in COPD and Th2/eosinophilic/Type-2 inflammatory pathways of asthma. The pharmacology of treating ACOS is challenging in severe circumstances.Areas covered: This review evaluates the stepwise treatment of ACOS using pharmacological treatments used in both COPD and asthma. The most common medications involve the same inhalers used to treat COPD...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 20 January 2020Source: Artificial Intelligence in MedicineAuthor(s): S. Jayalakshmy, Gnanou Florence SudhaAbstractAuscultation of the lung is a conventional technique used for diagnosing chronic obstructive pulmonary diseases (COPDs) and lower respiratory infections and disorders in patients. In most of the earlier works, wavelet transforms or spectrograms have been used to analyze the lung sounds. However, an accurate prediction model for respiratory disorders has not been developed so far. In this paper, a pre-trained optimized Alexnet Convolutional Neural Network (CNN) architecture is ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Condition:   COPD Exacerbation Interventions:   Drug: 5 days of systemic corticotherapy (prednisone);   Drug: 5 days of placebo Sponsor:   University Hospital, Montpellier Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 20 January 2020Source: Chemico-Biological InteractionsAuthor(s): Xin Nee Tew, Natalie Jia Xin Lau, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Murtaza M. Tambuwala, Alaa AA. Aljabali, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Gaurav Gupta, Brian G. Oliver, Alan Hsu, Peter Wark, Karosham Reddy, Ridhima Wadhwa, Philip Michael Hansbro, Kamal DuaAbstractInflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently,...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Peripheral neuropathy is a common comorbidity in COPD. We aimed to investigate associations between alterations commonly found in COPD and peripheral neuropathy, with particular emphasize on the distinction be...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Reduced physical capacity (PC) and physical activity (PA) are common in COPD patients and associated with poor outcome. However, they represent different aspects of physical functioning and interventions do no...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resti...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
ConclusionThe high Metrnl level in COPD exacerbations and active smoking may be important in balancing the inflammatory response. However, plasma Metrnl levels were found to be lower in COPD patients with comorbidities.
Source: Lung - Category: Respiratory Medicine Source Type: research
ConclusionThe beneficial impact of inhaled verapamil on the diminishing of dyspnea score along with its bronchodilatory effect would make this selective calcium blocker agent a therapeutic option in COPD.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
The right ventricle (RV) of the heart is affected with many pulmonary disorders including pulmonary hypertension. Here, we use RNA ‐seq. to characterize the altered genes in the RV and the left ventricle (LV) during hypoxia in a rat model. We compare changes in gene expression, but most importantly find a difference in immune cell‐related genes in the RV compared to the LV, and confirm this using flow cytometry and immuno blotting. AbstractChronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular re...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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