Treatable traits can be identified in a severe asthma registry and predict future exacerbations

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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Publication date: Available online 18 January 2020Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Linda Marie Schellenberg, Jana Bonicelli, Ina Hochheim, Ralf Regenthal, Getu AbrahamAbstractThe β-adrenergic receptor (β-AR) plays an important role in regulating a variety of cell and organ functions in different animal species and is an important target in asthma pathogenesis and therapy. The β-AR expression and function in equine bronchial epithelial cells (EBEC) were not known but innervation and significant decrease in receptor level were reported in the equine bronchial tissues from asthmatic ho...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection.Methods: This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 year before index, age ≥18 years at first HIV diagnosis and
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Khreis Air pollution is associated with premature mortality and a wide spectrum of diseases. Traffic-related air pollution (TRAP) is one of the most concerning sources of air pollution for human exposure and health. Until TRAP levels can be significantly reduced on a global scale, there is a need for effective shorter-term strategies to prevent the adverse health effects of TRAP. A growing number of studies suggest that increasing antioxidant intake, through diet or supplementation, may reduce this burden of disease. In this paper, we conducted a non-systematic literature review to assess the available evidence on ant...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Authors: Kalmarzi RN, Ahmadi S, Rahehagh R, Fathallahpour A, Khalafi B, Kashefi H, Roshani D, Zaryan RN, Mohamadi S, Kooti W Abstract BACKGROUND: The extensive impacts of vitamin D on the immune system has gathered the attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on clinical outcomes in asthmatic children with vitamin D insufficiency. MATERIALS &METHODS: This before-after interventional study was conducted on all asthmatic children who attended the Be...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
This study investigated the protective effects of ascorbic acid in combination with calcitriol on airway remodelling in ovalbumin (OVA)-induced chronic asthma.Materials and methods: BALB/c mice were assigned into seven groups: (1) Control; (2) Asthma; (3) Ineffective C (orally 39 mg/kg ascorbic acid); (4) Ineffective D (intraperitoneally 1.5 μg/kg calcitriol); (5) Effective C (orally 130 mg/kg ascorbic acid); (6) Effective D (intraperitoneally 5 μg/kg calcitriol); (7) Combination (orally 39 mg/kg ascorbic acid + intraperitoneally 1.5 μg/kg calcitriol). All an...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Publication date: Available online 16 January 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Yonghui Lv, Yu Wang, Xin Zheng, Guizhao LiangAbstractVEGFR2, vascular endothelial growth factor receptor 2, plays an important role in anti-angiogenesis and is an effective target for inhibiting tumor cell proliferation and metastasis. Many small molecule inhibitors have so far exhibited fine therapeutic effects but do not rule out some adverse reactions. From the perspective of the new use of old drugs, we use a combination of two different docking methods, molecular dynamics simulations and quantum-chemical cal...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Publication date: Available online 17 January 2020Source: Revista Clínica Española (English Edition)Author(s): E. Martínez-Moragón, J. Delgado, S. Mogrovejo, T. Fernández-Sánchez, On behalf of the grupo de investigación STEP, Jesús Jiménez López, Miguel Ángel Moscardó Orenes, Patricia Prieto Montaño, Miguel Torrecillas Toro, Begoña Cueva Oliver, Ángel Ferrer Torres, Purificación González Delgado, Teodorikez Wilfox Jiménez Rodríguez, Brian Vila Auli, Juan José Zapata Yebenes, Marí...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
BPA exposure may activate an immune system response linked to asthma that is passed down through generations, according to a study published in the journal ofProteome Research.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
The Pharmacogenomics Journal, Published online: 17 January 2020; doi:10.1038/s41397-019-0140-yPharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
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