Long noncoding RNA HOTAIR promotes the self-renewal of leukemia stem cells through epigenetic silencing of p15

Acute myeloid leukemia (AML) is characterized by the blockage of differentiation and uncontrolled proliferation. Although conventional chemotherapy and stem cell transplantation markedly improve the overall survival (OS) in AML patients, half of adult patients and more than 80% of older patients (>60 years) die as a result of primary refractoriness, relapse, or treatment-related mortality [1]. Various genetic mutations, such as c-Kit, FLT3, and WT1, lead to the initiation and development of AML [2].
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research