Impact of obesity on clinical outcomes of elderly patients undergoing allogeneic hematopoietic cell transplant for myeloid malignancies

Myeloid malignancies such as acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), are potentially life-threatening diseases of the elderly, occurring mostly in the seventh to eighth decades of life 1,2. The general approach to treatment is a form of induction chemotherapy followed by consideration of allogeneic hematopoietic cell transplant (allo-HCT) as consolidation therapy in select patients felt to have high-risk disease and be fit for transplantation. Historically, allo-HCT was reserved for young patients with an acceptable performance status but with the adaptation of reduced intensity and non-myeloablative regimens along with improved supportive care measures, the application of this procedure has been extended to older patients with more comorbid conditions 3.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research