Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylateRing nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate, Published online: 19 September 2018; doi:10.1038/s41586-018-0557-5In the CRISPR type III system, ‘ring’ nucleases possess a metal-independent mechanism that cleaves cyclic oligoadenylate ring molecules to switch off the antiviral state in cells.

Source: Nature AOP - September 19, 2018 Category: Research Authors: Januka S. Athukoralage Christophe Rouillon Shirley Graham Sabine Gr üschow Malcolm F. White Source Type: research