p53-loss mitigates early volume deficits in the brains of irradiated young mice

In the brain, radiation-induced apoptosis is largely mediated by p53. We used longitudinal magnetic resonance imaging in a mouse model to map radiation-induced changes in neuroanatomy and quantified the impact of knocking out p53. We observed mitigation of radiation-induced volume loss by p53-knockout one week after treatment, but this was not maintained to adulthood due to decreased growth.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Biology Contribution Source Type: research