Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial
Pregnancy of unknown location (PUL) is not a diagnosis but a transient state used to classify a woman when she has a positive pregnancy test without definitive evidence of an intra-uterine or extra-uterine pregnancy on transvaginal ultrasonography. Management of a persisting PUL varies substantially, including expectant or active management. Active management can include uterine cavity evacuation or systemic administration of methotrexate. To date, no consensus has been reached on whether either management strategy is superior or non-inferior to the other.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Kurt T. Barnhart, Mary D. Sammel, Mary Stephenson, Jared Robins, Karl R. Hansen, Wahid A. Youssef, Nanette Santoro, Esther Eisenberg, Heping Zhang, for the NICHD Cooperative Reproductive Medicine Network Source Type: research