Cancers, Vol. 10, Pages 341: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development

Cancers, Vol. 10, Pages 341: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development Cancers doi: 10.3390/cancers10090341 Authors: Sonia Leon-Cabrera Armando Vázquez-Sandoval Emmanuel Molina-Guzman Yael Delgado-Ramirez Norma Delgado-Buenrostro Blanca Callejas Yolanda Chirino Carlos Pérez-Plasencia Miriam Rodríguez-Sosa Jonadab Olguín Citlaltepetl Salinas Abhay Satoskar Luis Terrazas Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor–stroma interactions, and its expression and activity are perturbed during colon cancer. However, the role of STAT1 during the initiation of inflammation-associated cancer is not clearly understood. To determine the role of STAT1 in colitis-associated colorectal cancer (CAC), we analyzed the tumor development and kinetics of cell recruitment in wild-type WT or STAT1−/− mice treated with azoxymethane (AOM) and dextran sodium sulfate (DSS). Following CAC induction, STAT1−/− mice displayed an accelerated appearance of inflammation and tumor formation, and increased damage and scores on the disease activity index (DAI) as early as 20 days after AOM-DSS exposure compared to their WT counterparts. STAT1−/− mice showed elevated colonic epithelial cell pr...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research