Cancers, Vol. 10, Pages 341: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development
Cancers, Vol. 10, Pages 341: Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development
Cancers doi: 10.3390/cancers10090341
Authors:
Sonia Leon-Cabrera
Armando Vázquez-Sandoval
Emmanuel Molina-Guzman
Yael Delgado-Ramirez
Norma Delgado-Buenrostro
Blanca Callejas
Yolanda Chirino
Carlos Pérez-Plasencia
Miriam Rodríguez-Sosa
Jonadab Olguín
Citlaltepetl Salinas
Abhay Satoskar
Luis Terrazas
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor–stroma interactions, and its expression and activity are perturbed during colon cancer. However, the role of STAT1 during the initiation of inflammation-associated cancer is not clearly understood. To determine the role of STAT1 in colitis-associated colorectal cancer (CAC), we analyzed the tumor development and kinetics of cell recruitment in wild-type WT or STAT1−/− mice treated with azoxymethane (AOM) and dextran sodium sulfate (DSS). Following CAC induction, STAT1−/− mice displayed an accelerated appearance of inflammation and tumor formation, and increased damage and scores on the disease activity index (DAI) as early as 20 days after AOM-DSS exposure compared to their WT counterparts. STAT1−/− mice showed elevated colonic epithelial cell pr...
Source: Cancers - Category: Cancer & Oncology Authors: Sonia Leon-Cabrera Armando V ázquez-Sandoval Emmanuel Molina-Guzman Yael Delgado-Ramirez Norma Delgado-Buenrostro Blanca Callejas Yolanda Chirino Carlos P érez-Plasencia Miriam Rodr íguez-Sosa Jonadab Olgu ín Citlaltepetl Salinas Abhay Satoskar Luis T Tags: Article Source Type: research
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