Chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with BDNF, cofilin1 and Cdc42/RhoA alterations in immature mice.

CONCLUSION: Our data suggest that response similar to nicotine withdrawal or/and hypoxia induced by childhood chronic asthma enhances the BDNF-Cdc42/RhoA signaling pathway and activates cofilin1, leading to the remodeling of actin, causing the loss of dendritic spines and atrophy of dendrites, eventually resulting in behavioral alterations. PMID: 30227235 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30227235?dopt=Abstract

Source: Brain Research Bulletin - September 15, 2018 Category: Neurology Authors: Zhuang TT, Pan C, Chen JJ, Han F, Zhu XL, Xu H, Lu YP Tags: Brain Res Bull Source Type: research