Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-Mutant Lung Cancer.

CONCLUSIONS: BRAF-mutant NSCLC is a heterogeneous disease that encompasses three distinct functional classes. Classes II and III have aggressive clinical features leading to less favorable outcomes. The distinct biological characteristics of class II and III tumors suggest that class-specific therapies may be necessary to effectively target these molecular subsets.
PMID: 30224342 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 17, 2018 Category: Cancer & Oncology Authors: Dagogo-Jack I, Martinez P, Yeap BY, Ambrogio C, Ferris LA, Lydon C, Nguyen T, Jessop NA, Iafrate AJ, Johnson BE, Lennerz JK, Shaw AT, Awad MM Tags: Clin Cancer Res Source Type: research