Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy

Roles of the RANKL–RANK axis in antitumour immunity — implications for therapyRoles of the RANKL–RANK axis in antitumour immunity — implications for therapy, Published online: 19 September 2018; doi:10.1038/s41571-018-0095-yIntriguing evidence suggests that expression of RANK or RANKL by various cells of the tumour microenvironment modulates the anticancer immune response. Herein, the authors review this evidence, discuss the current preclinical and clinical data supporting a potential of RANKL inhibition to improve anticancer immunotherapy and describe hypothetical immune-related mechanisms of action.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Source Type: research