Insights into endotoxin-mediated lung inflammation and future treatment strategies.

Insights into endotoxin-mediated lung inflammation and future treatment strategies. Expert Rev Respir Med. 2018 Sep 15;: Authors: Chakraborty A, Boer JC, Selomulya C, Plebanski M, Royce SG Abstract INTRODUCTION: Airway inflammatory disorders are prevalent diseases in need of better management and new therapeutics. Immunotherapies offer a solution to the problem of corticosteroid resistance. Areas covered: The current review focuses on lipopolysaccharide (Gram-negative bacterial endotoxin)- mediated inflammation in the lung and the animal models used to study related diseases. Endotoxin-induced lung pathology is usually initiated by antigen presenting cells (APC). We will discuss different subsets of APC including lung dendritic cells (DC) and macrophages, and their role in responding to endotoxin and environmental challenges. Expert commentary: The pharmacotherapeutic considerations to combat airway inflammation should cost-effectively improve quality of life with sustainable and safe strategies. Selectively targeting APCs in the lung offers the potential for a promising new strategy for the better management and treatment of inflammatory lung disease. PMID: 30221563 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research