WNT Signaling in Cancer Immunosurveillance.

WNT Signaling in Cancer Immunosurveillance.
Trends Cell Biol. 2018 Sep 13;:
Authors: Galluzzi L, Spranger S, Fuchs E, López-Soto A
Abstract
Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.
PMID: 30220580 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - September 13, 2018 Category: Cytology Authors: Galluzzi L, Spranger S, Fuchs E, López-Soto A Tags: Trends Cell Biol Source Type: research