Minimum breast distance largely explains individual variability in doses to contralateral breast from breast-cancer radiotherapy

Adjuvant whole-breast radiotherapy is a recommended part of breast-cancer therapy after breast-conserving surgery. It reduces the recurrence rates of breast cancer, specific mortality from breast cancer as well as the overall mortality [1]. However, breast-cancer radiotherapy also increases the incidence of second cancers, mainly in the contralateral breast and in the lungs. Especially for left-sided tumours it also increases the mortality through heart disease [1,2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research

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By STEVE ZECOLA Americans spend about $3 trillion per year on healthcare, or about $10,000 per person per year. Despite these expenditures, Americans are worse off than their international counterparts with respect to infant mortality, life expectancy and the prevalence of chronic conditions. In policy debates, Republicans mostly prefer to let the marketplace devise the appropriate outcomes, but this approach ignores the market failures that plague the industry. On the other hand, Democrats propose a variety of solutions such as “Medicare for All” which nationalizes all healthcare insurance or, as a va...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Medicare For All Source Type: blogs
ConclusionWomen with breast cancer had a higher risk of developing new comorbidities than women without cancer. Development of coordinated care models to manage multiple chronic diseases among breast cancer patients is warranted.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Title: Heart Disease Is Lasting Threat to Breast Cancer SurvivorsCategory: Health NewsCreated: 6/21/2019 12:00:00 AMLast Editorial Review: 6/24/2019 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news
New research confirms that women who have undergone breast cancer therapy are more at risk of cardiovascular disease, and it also shows why this may be.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news
(The North American Menopause Society (NAMS)) Thanks to advanced medical treatments, women diagnosed with breast cancer today will likely survive the disease. However, some treatment options put these women at greater risk for a number of other health problems. A new study out of Brazil shows that postmenopausal women with breast cancer are at greater risk for developing heart disease. Results are published online in Menopause, the journal of The North American Menopause Society (NAMS).
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study aimed to reduce the risk of cardiovascular events through an optimization of the dose distribution on heart substructures in mediastinal HL patients with the adoption of different volumetric modulated arc therapy (VMAT) techniques, while maintaining the same risk of second cancer induction on lungs and breasts. MATERIALS AND METHODS: Thirty patients (15 males and 15 females, 15 bulky lesions) treated between 2012 and 2017 at our institution were selected. Disease extent was mediastinum plus neck (n = 10), mediastinum plus unilateral axilla (n = 10) and mediastinum alone (n = 10). Lungs, breasts,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
AbstractThe number of breast cancer (BC) survivors has been increasing lately, due to the improvement in early detection strategies and oncological treatments. However, BC survivors are 3 times as likely to develop heart failure (HF) within 5  years of cancer diagnosis, and 7/100 of them will develop HF in a median follow-up of 8.5 years. Furthermore, HF in BC survivors has a worse prognosis compared to other causes of HF. Anthracyclines and trastuzumab have been proven to improve survival. However, they are also considered as the main causative factors of HF in BC survivors. Old patients, those with a pre-existi...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Conclusions: We successfully designed and synthesized a novel radiotracer 68Ga-NOTAGA-GAP19 that targets Connexin43. Experiments in vitro demonstrated that the molecular probe 68Ga-NOTAGA-GAP19 can bind to Connexin43 in non-small cell lung cancer cell lines. Further research on this probe is necessary to verify its stability and imaging effect in vivo.Reference: [1] Schulz R, Gorge PM, Gorbe A, Ferdinandy P, Lampe PD, and Leybaert L. Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther. 2015;153:90-106. [2] Grek CL, Rhett JM, Bruce JS, Ghatnekar ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiochemistry & amp; Chelation Posters Source Type: research
WEDNESDAY, May 15, 2019 -- Health experts have long touted the benefits of a low-fat diet for preventing heart disease, but now a large study suggests it might do the same against breast cancer. Researchers found that eating low-fat foods reduced a...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The unexpected early termination of the WHI Trial of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) in mid-2002 triggered a rapid and dramatic decline in the use of MHT worldwide. This effect was primarily due to fears of increased risks for breast cancer and coronary heart disease purportedly seen in the cohort overall - aged 50 to 79 on randomization (mean 63 years and 12 years postmenopausal); a cohort comprised primarily of women much older than those who would typically be started on MHT in clinical practice.
Source: Maturitas - Category: Primary Care Authors: Tags: INV49 Source Type: research
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