Biotech co. hosts career fair at new Pearland facility, aims to hire 200 by end of 2019

Switzerland-based biotech giant Lonza Group Ltd. is moving forward with plans to double its workforce at its recently opened Pearland facility, billed as the largest dedicated cell and gene therapy manufacturing facility in the world. The 300,000-square-foot facility officially opened in April with 170 employees. Ricardo Jimenez, site director at Lonza Houston Inc., told the Houston Business Journal at the time that the space could support more than 400 workers.  Now, the company is holding its…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Abstract Parvoviruses are highly attractive templates for the engineering of safe, efficient, and specific gene therapy vectors, as best exemplified by adeno-associated virus (AAV). Another candidate that currently garners increasing attention is human bocavirus 1 (HBoV1). Notably, HBoV1 capsids can cross-package recombinant (r)AAV2 genomes, yielding rAAV2/HBoV1 chimeras that specifically transduce polarized human airway epithelia (pHAEs). Here, we largely expanded the repertoire of rAAV/BoV chimeras, by assembling packaging plasmids encoding the capsid genes of four additional primate bocaviruses, HBoV2...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Mol Ther Methods Clin Dev Source Type: research
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 15 February 2019Source: Carbohydrate PolymersAuthor(s): Jing Miao, Xi-qin Yang, Zhe Gao, Qian Li, Ting-ting Meng, Jia-ying Wu, Hong Yuan, Fu-qiang HuAbstractDrzBC and DrzBS (10-23DNAzyme) could block the expression of HBV e- and s- gene respectively. But the application of 10-23DNAzyme was limited owing to the lack of appropriate delivery vehicles. Chitosan oligosaccharide-SS-Octadecylamine (CSSO), a redox-responsive nano-sized polymeric carrier, could self-aggregate and bind with DNA by electrostatic interaction at proper mass ratio. Compared with the traditional commercial carrier Lipo2...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
lsson L Abstract Chemically modified mRNA is a novel, highly efficient, biocompatible modality for therapeutic protein expression that may overcome the challenges and safety concerns with current gene therapy strategies. We explored the efficiency of intradermally injected modified VEGF-A165 mRNA (VEGF-A mRNA) formulated in a biocompatible citrate/saline buffer to locally produce human VEGF-A165 protein. Rabbits (n=4) and minipigs (n=3) were implanted with subcutaneous microdialysis probes close to the injection sites and interstitial-fluid samples and skin biopsies were analysed for production of VEGF-A protein o...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
The company will tap Wilson ’s lab to develop gene therapies for rare central nervous system diseases
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Conclusions: It is expected that new therapies, such as intrathecal therapies or gene therapy could be evaluated in the different types of LSD demonstrating positive effects, especially in the previous phenotypes.
Source: Health Policy and Technology - Category: Health Management Source Type: research
Authors: Chistiakov DA, Tyurina I Abstract Insulin gene therapy is an approach that might overcome the weakness of islet cell therapy owing to its vulnerability to autoimmune attack. There are several mandatory conditions for successful insulin gene therapy. Efficient insulin gene therapy should have an effective insulin gene delivery mechanism, a system of regulation of the insulin biosynthesis that responds to glucose within extremely narrow physiological limits, a system of insulin processing into its active form and a choice of appropriate target cells, which possess biochemical characteristics similar to &beta...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor, Published online: 15 February 2019; doi:10.1038/s41434-019-0062-yscFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor
Source: Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain, Published online: 15 February 2019; doi:10.1038/s41434-019-0063-xRegulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain
Source: Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
Human Gene Therapy Methods,Volume 30, Issue 1, Page 1-16, February 2019.
Source: Human Gene Therapy Methods - Category: Genetics & Stem Cells Authors: Source Type: research
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