Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease

Diverticular disease (DD) is one of the most prevalent diseases of the large bowel. Lately, imbalance of neuro-muscular transmission has been recognized as a major etiological factor for DD. Neuronal calcitonin gene-related peptide (CGRP) is a potent gastrointestinal smooth muscle relaxant shown to have a widespread effect within the alimentary tract. Nevertheless, CGRPergic innervation of the enteric ganglia has never been considered in the context of motility impairment observed in DD patients.

Source: Autonomic Neuroscience: Basic and Clinical - September 18, 2018 Category: Neuroscience Authors: A.G. Pauza, K. Rysevaite-Kyguoliene, M. Malinauskas, J.I. Lukosiene, P. Alaburda, E. Stankevicius, J. Kupcinskas, Z. Saladzinskas, A. Tamelis, N. Pauziene Source Type: research