Obstructive sleep apnoea and cholesterol: Independence in context

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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CONCLUSION: Korean patients with OSA frequently had comorbid metabolic syndrome. Moderate to severe OSA during REM sleep may be a predictor of metabolic syndrome. PMID: 31898193 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
ConclusionKorean patients with OSA frequently had comorbid metabolic syndrome. Moderate to severe OSA during REM sleep may be a predictor of metabolic syndrome.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
This study aimed to systematically identify subcutaneous adipose tissue transcriptional programs modulated in OSA and in response to its effective treatment with CPAP. Two subject groups were investigated: Study Group 1 was comprised of 10 OSA and 8 controls; Study Group 2 included 24 individuals with OSA studied at baseline and following CPAP. For each subject, genome-wide gene expression measurement of subcutaneous fat was performed. Differentially activated pathways elicited by OSA (Group 1) and in response to its treatment (Group 2) were determined using network and Gene Set Enrichment Analysis (GSEA). In Group 2, trea...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Seven risk factors including age (every 5  years), low‐density lipoprotein‐cholesterol, smoking, body mass index, diabetes, obstructive sleep apnea syndrome, and aspartate aminotransferase (every 5 units) were independent indicators of 8‐year cancer events in patients with NAFLD. A simple risk model and a score system were developed to predict the risk of cancer events after NAFLD based on 8‐year follow‐up of 1254 NAFLD patients. The risk model was well validated in the test samples (n = 627) and evaluation samples (n = 627) with 8‐year follow‐up. Importantly, the risk model performed...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS:The findings of this study indicated a high prevalence of obstructive sleep apnea among locomotive drivers. Therefore, further research is warranted to re-evaluate the current screening regulations of diagnosing sleep apnea among locomotive drivers. PMID: 31868718 [PubMed - as supplied by publisher]
Source: Work - Category: Occupational Health Authors: Tags: Work Source Type: research
Purpose: Obstructive sleep apnoea (OSA) is associated with an increased risk for hypertension, diabetes and dyslipidaemia. Both OSA and its comorbidities are at least partly heritable, suggesting a common genetic background for them. Twin studies can help analysing the heritability of OSA and its association with comorbidities.Methods: 47 monozygotic and 22 dizygotic adult twin pairs were recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) who attended an overnight diagnostic polysomnography. Medical history was taken, blood pressure was measured, blood samples were taken for fasting glucose, total c...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Introduction and Aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia and nocturnal hypoxia plays an important role in this association. The aim of the current study was to examine the effects of OSA alleviation by PAP treatment on cholesterol levels.Methods: In the present prospective cohort study, 1564 OSA subjects from 9 centers of the ESADA database undergoing PAP therapy for at least 3 months were identified (mean age 54±11y, BMI 32.7±6.6kg/m2, 74% male and AHI 40.3±24.4 n/h). Baseline and follow-up total cholesterol concentrations were examined. Repeated measures and ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
This study investigates the association between OSA severity and prevalence of hyperlipidemia in patients of the ESADA cohort.Methods: The cross-sectional analysis included 11,892 patients (age 51.9±12.5 years, 70% male, BMI 31.3±6.6 kg/m2, mean ODI 23.7±25.5 n/h) investigated for OSA. The independent OR for hyperlipidemia in relation to measures of OSA (ODI, AHI, mean and lowest SpO2) was determined by means of General Linear Model analysis with adjustment for important confounders like age, BMI, comorbidities, and study site.Results: Hyperlipidemia prevalence increased from 15.1% in subjects without ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
A 40-year-old man was treated with tonsillectomy and underwent early surgical exploration because of bleeding. Postoperative bleeding complications were treated with bronchoscopy. In addition to obesity, normal thyroid function, type 2 diabetes mellitus, and current tobacco abuse with severe obstructive sleep apnea syndrome, biochemistry revealed severe hypercholesterolemia (total cholesterol 572 mg/dL) and hypertriglyceridemia (1,220 mg/dL). During the postoperative period, low doses of propofol (up to 2 mg/kg/h for 10 hours), along with remifentanil (up to 0.0016 mg/kg/h for 20 hours), midazolam, and tramadol, were neede...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Letter to the Editor Source Type: research
CONCLUSIONS: Patients with OSA have elevated serum levels of high-sensitivity-CRP, a marker for inflammation and an independent risk predictor for cardiovascular morbidity. PMID: 31646893 [PubMed - as supplied by publisher]
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
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