Increasing burden of noninfectious lung disease in persons living with HIV: a 7-year study using the French nationwide hospital administrative database

An overall reduction in the incidence of AIDS and a change in the spectrum of lung disease have been noticed in persons living with HIV (PLHIV). Our aim was to provide an epidemiological update regarding the prevalence of lung diseases in PLHIV hospitalised in France. We analysed the prevalence of lung disease in PLHIV hospitalised in France from 2007 to 2013, from the French nationwide hospital medical information database, and assessed the association between HIV and incident noninfectious disease over 4 years of follow-up. A total of 52 091 PLHIV were hospitalised in France between 2007 and 2013. Among PLHIV hospitalised with lung disease, noninfectious lung diseases increased significantly from 45.6% to 54.7% between 2007 and 2013, whereas the proportion of patients with at least one infectious lung disease decreased significantly. In 2010, 10 067 prevalent hospitalised PLHIV were compared with 8 244 682 hospitalised non-PLHIV. In 30–49-year-old patients, HIV infection was associated with chronic obstructive pulmonary disease (COPD), chronic respiratory failure, emphysema, lung fibrosis and pulmonary arterial hypertension (PAH) even after adjustment for smoking. The emergence of noninfectious lung disease, in particular COPD, emphysema, lung fibrosis, PAH and chronic respiratory disease, in PLHIV would justify mass screening in this population.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Rare lung diseases Source Type: research

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ConclusionNo significant difference was found in the clinical manifestations, mortality, and complication between children and adults but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: Available online 21 May 2019Source: Comptes Rendus PhysiqueAuthor(s): Guy LavalAbstractAt their very beginning, the researches on the magnetic confinement fusion had to face up plasma instabilities. Macroscopic plasma instabilities were the first ones to be identified and they were found to be very harmful for plasma confinement. During the first years after the Atoms for Peace Meeting in 1958, the main goals of experimental and theoretical researches dealt with their suppression or control. During this period, two special types of instabilities, the localized interchange modes and the tearing modes, were...
Source: Comptes Rendus Physique - Category: Physics Source Type: research
Abstract OBJECTIVE: To determine the use of home care services in those with and without visual impairment in Canada. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Participants came from the baseline examination of the Canadian Longitudinal Study on Aging Comprehensive Cohort. Inclusion criteria included age between 45 and 85 years, community dwelling, and living near one of the 11 data collection sites across 7 Canadian provinces. People were excluded if they were in an institution, were living on a First Nations reserve, were full-time members of the Canadian Armed Forces, did not speak...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSIONS: The prevalence of ocular hypertension and glaucoma based on suspect optic nerves in our sample population was high, indicating a strong need for access to ophthalmologic care in the Haitian population. PMID: 31109474 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSION: The questionnaire will be a valuable aid in screening for Charles Bonnet syndrome among the low vision clientele. However, the screening will need to be supplemented by a focused low vision interdisciplinary assessment including a visual examination and a clinical interview with a psychologist. PMID: 31109471 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Publication date: Available online 22 May 2019Source: Molecular Phylogenetics and EvolutionAuthor(s): Connor M. French, Michael S. Deutsch, Germán Chávez, Carlos Eduardo Almora, Jason L. BrownAbstractThe Tropical Andes contains exceptionally high diversity, much of it arising within the Quaternary period. The complex geology of the Andes and paleoclimate fluctuations within the Quaternary suggest complex speciation scenarios. This, in turn, has contributed to idiosyncratic speciation modes among shallowly diverged Amazonian taxa. Many relationships among these taxa remain poorly resolved. Here, we use a seque...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Conclusions: Better definitions for TDF-associated toxicity are needed. uPCR is not a very good indicator of TDF-associated tubular dysfunction. Omani patients with HIV on TDF have a 4% prevalence of renal toxicity, but a study with a larger number of patients is required to explore this observation further. Cofactors like duration of TDF use, age, BMI, gender, diabetes mellitus, and use of protease inhibitors did not have an impact on the severity of FEPi and uPCR. PMID: 31110631 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Publication date: Available online 21 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
Go online to to view the activity, download slides and practice aids, and complete the post-test to earn credit. This PeerView CME/CNE-certified activity—based on a live event conducted in a MasterClass format held in conjunction with the 2019 meeting of the AACR—discusses how Bruton tyrosine kinase (BTK) inhibitors effectively target aspects of B-cell receptor signaling and covers key evidence and clinical issues related to the use of BTK inhibitors in hematologic malignancies (including agent selection, potential combination regimens, and strategies for overcoming drug intolerance or resis...
Source: Peerview CME/CE Video Podcast - Internal Medicine International - Category: Internal Medicine Authors: Tags: Science, Medicine Source Type: video
ConclusionsAmbulatory blood pressure monitoring is superior to casual office BP obtained at time of dialysis in delineating cardiovascular morbidity in adolescent and young adult HD patients. CBP is easily performed and correlates with LVMI and PWV in adolescent and young adult HD patients; however, large-scale normative data is needed.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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