Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus

Staphylococcus aureus is a major cause of both community- and hospital-acquired infections and represents a significant burden on the healthcare system. In addition, S. aureus is also involved in infections of medical implants and host tissue due to its ability to form biofilms, which play an important role in the persistence of chronic infections [1, 2]. A biofilm is defined as a sessile microbial community in which microorganisms live attached to a surface in a highly hydrated extracellular matrix [3], which in case of S.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research