Incidence and Risk Factors for Acquisition of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Newborns after Birth in Seville, Spain: a Prospective Cohort Study

Extended-spectrum β-lactamases (ESBL) confer resistance to penicillins and cephalosporins except cephamycins; bacteria producing ESBL are also frequently resistant to non β-lactam antibiotics such as fluoroquinolones, trimethoprim-sulphamethoxazole and aminoglycosides, and therefore are multidrug-resistant. ESBLs a re mostly produced by Enterobacteriaceae and have spread worldwide over the last 20 years both in the community and in hospitals [1, 2]. ESBL-producing Enterobacteriaceae (ESBL-E) are responsible for an increasing number of cases of nosocomial and community sepsis in newborns, and of outbreaks in ne onatal intensive care units, resulting in high morbidity and mortality [3–5].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research