Synergistic and bactericidal activities of mecillinam, amoxicillin and clavulanic acid combinations against ESBL-producing Escherichia coli in 24-h time-kill experiments

The increasing prevalence of Escherichia coli producing extended-spectrum beta-lactamases (ESBLs) has become a major challenge in the management of patients with urinary tract infections (UTI) [1]. Therapeutic options are limited, especially for oral administration, due to the frequent co-resistance to multiple β-lactam antibiotics, quinolones and trimethoprim in these strains [1]. Therefore, there is a need to re-evaluate old antibiotics that are still active against ESBL-producing E. coli and to learn more about how the efficacy of these drugs can be enhanced by optimal dosing or use of combination ther apy.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research