Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders

Publication date: Available online 17 September 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Dusan Hirjak, Andreas Meyer-Lindenberg, Stefan Fritze, Fabio Sambataro, Katharina M. Kubera, Robert C. WolfAbstractAlthough genuine motor abnormalities (GMA) are frequently found in schizophrenia, they are also considered as an intrinsic feature of bipolar, obsessive-compulsive, and neurodevelopmental disorders with early onset such as autism, ADHD, and Tourette syndrome. Such transnosological observations strongly suggest a common neural pathophysiology. This systematic review highlights the evidence on GMA and their neuroanatomical substrates in bipolar, obsessive-compulsive, and neurodevelopmental disorders. The data lends support for a common pattern contributing to GMA expression in these diseases that seems to be related to cerebello-thalamo-cortical, fronto-parietal, and cortico-subcortical motor circuit dysfunction. The identified studies provide first evidence for a motor network dysfunction as a correlate of early neurodevelopmental deviance prior to clinical symptom expression. There are also first hints for a developmental risk factor model of these mental disorders. An in-depth analysis of motor networks and related patho-(physiological) mechanisms will not only help promoting RDoC Motor System construct, but also facilitate the development of novel psychopharmacological models, as well as the identification of neurobiologically plausible target sites for...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Publication date: Available online 2 June 2020Source: American Journal of OtolaryngologyAuthor(s): Saad Elzayat, Hossam Elsherif, Ihab Nada, Ragaey Youssef
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
The hidden links between mental disorders (Nature): In 2018, psychiatrist Oleguer Plana-Ripoll was wrestling with a puzzling fact about mental disorders. He knew that many individuals have multiple conditions — anxiety and depression, say, or schizophrenia and bipolar disorder. He wanted to know how common it was to have more than one diagnosis, so he got his hands on a database containing the medical details of around 5.9 million Danish citizens. He was taken aback by what he found. Every single mental disorder predisposed the patient to every other mental disorder — no matter how distinct the symptoms. &ldquo...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology anxiety biological bipolar-disorder depression Genetics JAMA Psychiatry mental illness mental-disorders National-Institute-of-Mental-Health neuroanatomy psychopathology Resear Source Type: blogs
[Thoughts on a favourable evolution of a COVID-19 in a patient with resistant schizophrenia and on a combination of clozapine and paliperidone palmitate]. Encephale. 2020 May 21;: Authors: Bouaziz N, Ben Rejeb H, Ateb S, Fourati T, Chammas F, Baha D, Rosetti R, Kalalou K, Saba G, Benadhira R, Januel D PMID: 32475694 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
I am 23, just graduated with BA with a 2.992 in an irrelevant major with no prerequisites except maybe statistics with I got a A- Let say if I do a post-bacc with all the prereqs and will: - provide clinical/shadowing experiences - let's imagine I will get a 3.5 to 3.7 GPA in the post bacc -Let say a 505 in the MCAT Experiences so far: worked as a part-time direct support professional and took care of autistic children for around 2 years during college Hobbies: can draw on a hyperrealism... Guys, to be blunt, what are my changes? Should I give up?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
Publication date: Available online 1 June 2020Source: Brain, Behavior, and ImmunityAuthor(s): Elin Skott, Liu L. Yang, Miranda Stiernborg, Åsa Söderström, Joelle Ruegg, Martin Schalling, Yvonne Forsell, MaiBritt Giacobini, Catharina Lavebratt
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
In this study, we investigate the effect of clozapine on MK-801-induced neurochemical and neurobehavioral alterations in the prefrontal cortex of mice. Acute administration of NMDA noncompetitive antagonist MK-801 impairs motor coordination, grip strength, and locomotor activity. Clozapine is the only medication that is indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents; however, its mechanism is not well understood. To understand its mechanism, we investigated the effects of clozapine on motor coordination, locomotor activity, and grip strength in mice against the ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - Category: Environmental Health Tags: J Environ Pathol Toxicol Oncol Source Type: research
CONCLUSION: For the majority of the physicians surveyed, psychiatry represented a public health priority, and their prioritising provides a probable explanation for their positive perception of their role in the management of mental disorders. However, we went on to observe that a number of difficulties constituted obstacles to their role in management of mental disorders and induced them to refer their patients to psychiatrists. Our analysis highlighted the impact of continuing education on physicians' attitudes and the interest of collaboration between practitioners. Efforts in university teaching and continuous educatio...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
(University of Barcelona) An international study published in the journal Cell, has described 109 genetic variants associated with eight psychiatric disorders: autism, ADHD, schizophrenia, bipolar disorder, depression, obsessive-compulsive disorder and Tourette Syndrome, in a total of about 230,000 patients worldwide.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardiñas AF, Stahl E, Walters JTR, Walters R, Sullivan PF, Posthuma D, Polderman TJC PMID: 30334498 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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