The clinical presentation, utilization, and outcome of individuals with sickle cell anaemia presenting to urban emergency department of a tertiary hospital in Tanzania

We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.MethodsThis was a prospective cohort study of consecutive patients with SCA presenting to ED between December 2014 and July 2015. Informed consent was obtained from all patients or patients ’ proxies prior to being enrolled in the study. A standardized case report form was used to record study information, including demographics, relevant clinical characteristics and overall patients outcomes. Categorical variables were compared with chi-square test or Fisher’s exact test; continuo us variables were compared with two-sample t-test or Mann-Whitney U-test.ResultsWe enrolled 752 (2.7%) people with SCA from 28,322 patients who presented to the MNH-ED. The median age was 14  years (Interquartile range [IQR]: 6–23 years), and 395 (52.8%) were female. Pain 614 (81.6%), fever 289 (38.4%) were the most frequent presenting complaint. Patients with fever, hypoxia, altered mental status and bradycardia had statistically significant relative risk of mortality of 10.4, 153, 50 and 12.1 (p 
Source: BMC Hematology - Category: Hematology Source Type: research

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Publication date: Available online 19 February 2020Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
This study was aimed to estimate the prevalence of chronic pain in different regions of China. Data on pain and its treatment were collected from 9357 participants using questionnaires and telephone-based interviews, from 31 regions of China. Gathered data were then coded into electronic data acquisition system and descriptive and inferential statistical analysis was performed. Out of 9298 participants, the ratio of chronic pain was 31.54% with the proportion of male having chronic pain (33.86%) was higher than that of female (29.53%). The average age of participants with pain (45.02 ± 15.07 years) was higher than f...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
PMID: 32068583 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
PMID: 32068588 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
ConclusionsDespite published reports showing benefit for pain control in patients with BPA, the overall low quality, retrospective evidence included in this review highlights the need for a rigorous prospective study to further address this indication.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
Authors: Sepolvere G, Tedesco M, Fusco P, Scimia P, Cristiano L PMID: 32068984 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Hydroxyurea is a potent and safe disease-modifying therapy for sickle cell anemia (SCA), with available data proving laboratory and clinical efficacy for both children and adults. Although the global burden of SCA is greatest within sub-Saharan Africa, almost all studies with hydroxyurea to date have been conducted in the US and Europe. Since additional comorbidities may affect children with SCA in low-resource settings, including malnutrition, malaria, and other infections, prospective research is needed to develop locally appropriate guidelines for hydroxyurea use.To assess the feasibility, safety, and benefits of hydrox...
Source: Blood - Category: Hematology Authors: Tags: Plenary Scientific Session Source Type: research
Abstract Despite its well‐described safety and efficacy in the treatment of sickle cell anemia (SCA) in high‐income settings, hydroxyurea remains largely unavailable in sub‐Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open‐label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub‐Saharan African countries. Following comprehensive training of local researc...
Source: American Journal of Hematology - Category: Hematology Authors: Tags: Research Article Source Type: research
CONCLUSION: For Belgian medical students, SCD is an exotic disease. Too little information about SCD is delivered. Continuing medical education about SCD can be recommended for medical students in Belgium. PMID: 24388739 [PubMed - indexed for MEDLINE]
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
Imagine: inside the veins of an African-American child, red blood cells: round and soft, doing their job, keeping the person alive. What would happen if those cells hardened and changed shape, curving into the letter "C", like a wheat-cutting sickle? First, the capillaries would clog, in what Sickle Cell Disease (SCD) doctors call a "crisis". Excruciating agony, like broken glass in the veins, a crisis may last an hour or a day, and the pain is just the beginning. "By twenty years of age, about 15% of children with SCD suffer major strokes...by 40 years of age, almost half have central nervous sys...
Source: Science - The Huffington Post - Category: Science Source Type: news
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