The physiological role of the free 20S proteasome in protein degradation: A critical review

Publication date: Available online 16 September 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Marilene Demasi, Fernanda M. da CunhaAbstractBackgroundIt has been almost three decades since the removal of oxidized proteins by the free 20S catalytic unit of the proteasome (20SPT) was proposed. Since then, experimental evidence suggesting a physiological role of proteolysis mediated by the free 20SPT has being gathered.Scope of reviewExperimental data that favors the hypothesis of free 20SPT as playing a role in proteolysis are critically reviewed.Major conclusionsProtein degradation by the proteasome may proceed through multiple proteasome complexes with different requirements though the unequivocal role of the free 20SPT in cellular proteolysis towards native or oxidized proteins remains to be demonstrated.General significanceThe biological significance of proteolysis mediated by the free 20SPT has been elusive since its discovery. The present review critically analyzes the available experimental data supporting the proteolytic role of the free or single capped 20SPT.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - September 17, 2018 Category: Biochemistry Source Type: research